Aging eyes Youth protein may be key for prevention treatment
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Aging eyes Youth protein may be key for prevention treatment

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Aging eyes Youth protein may be key for prevention treatment
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  • The “youth” protein, pigment epithelium-derived factor (PEDF), protects cells in the eye’s retina from oxidative stress, a new animal study shows.
  • Researchers with the National Eye Institute (NEI) found that declines in PEDF levels may contribute to aging-related diseases of the retina.
  • Experts hope these findings will lead to developing new therapies that can reverse or counter the effects of PEDF loss.

The retina is composed of tissues in the back of the eye that process light signals and send them to the brain. Retinal pigment epithelium (RPE) cells make up part of this important structure for vision.

A recent animal study by the National Eye InstituteTrusted Source, part of the National Institutes of HealthTrusted Source, suggests that the loss of a certain protein could cause RPE cells to stop nourishing and recycling photoreceptor cells.

The resulting senescenceTrusted Source or deterioration of RPE cells may trigger the onset of diseases like age-related macular degeneration (AMD) and retinal dystrophies. These conditions are known to cause progressive vision loss.

A team led by Dr. Patricia Becerra, senior investigator at the NEI’s Section of Protein Structure and Function, discovered that the pigment epithelium-derived factor (PEDF) plays an anti-aging function for RPE cells. Their findings could offer the potential for finding new ways to treat or prevent aging-associated retinal diseases.

This study was published in the International Journal of Molecular Sciences.

PEDF, the “youth” protein

The RPE produces and secretes PEDF via the Serpinf1Trusted Sourcegene. PEDF is called the “youth” protein due to its abundance in young retinas.

RPE production and PEDF secretion decline during senescence and aging in the eyes, skin, lungs, and other tissues.

Earlier research suggests that PEDF can protect photoreceptor cells from damage and inhibit the growth of abnormal blood vessels in the eye.

However, Dr. Becerra stated: “We always wondered if loss of PEDF was driven by aging or was driving aging.”

Evidence from PEDF-negative mice

To find the answer, Dr. Becerra and her colleagues used a mouse model bioengineered without the PEDF gene Serpinf1.

Looking into the cellular structure of the models’ retinas, the researchers discovered remarkable differences from the control samples of wild-type mice.

The RPE cell nuclei were enlarged, which could indicate differences in how the cells’ DNA was arranged. These cells had also activated four genes associated with cellular senescence and aging.

Dr. Ivan Rebustini, a staff scientist in Dr. Becerra’s lab and the study’s lead author, remarked: “One of the most striking things was this reduction in the PEDF receptor on the surface of the RPE cells in the mouse lacking the PEDF protein. It seems there’s some sort of feedback-loop involving PEDF […]”

These changes led the team to conclude that PEDF decline prompts the aging of retinal cells.

The study’s limitations and potential

This study may uncover ways to help reduce age-related vision problems, but it does come with a few limitations.

What’s causing PEDF loss?

Although the research proposes that PEDF may drive aging, its results do not answer what’s causing PEDF loss.

In an interview with Medical News Today, Dr. Becerra explained: “Besides PEDF, there are other proteins that are dysregulated in various epithelial tissues—including the RPE—during aging. Besides changes in the expression and production of aging-related proteins, telomere shortening has been associated with aging, and is observed in epithelial tissues with high turnover, like the skin.”

“Telomeres are a structure at the end of a chromosome that maintains the integrity of our genes and are a critical factor for age-related diseases. Their shortening can affect the expression of genes during aging; the PEDF gene, Serpinf1, is one of them,” she continued.

“However, the extent to which this is driving PEDF loss in the eye is unknown,” she added.

MNT also discussed this study with Dr. Howard R. Krauss, surgical neuro-ophthalmologist of Pacific Neuroscience Institute at Providence Saint John’s Health Center in Santa Monica, CA, who was not involved in this research.

Dr. Krauss shared that while “we understand the vital importance of this protein and […] that its availability declines with age and/or degenerative disease, [w]e do not know what causes the loss.”

He agreed that PEDF depletion is just one of many factors behind RPE aging. He noted that identifying more factors may be necessary for reducing or reversing age-related damage.

Mouse-to-human trial challenges

The present work analyzed mouse models, which would be difficult to translate to human trials, Dr. Krauss cautioned.

For instance, Dr. Becerra noted that “the lack of a macula in the mouse’s retina means the parallels to conditions like age-related macular degeneration are not as clear as they might be in a species with that structure.”

According to Dr. Krauss: “[T]here will be no assurance that what may work in this mouse model will ultimately be of value in humans.”

Further, Dr. Becerra told MNT that, because samples from patients without PEDF are scarce, replicating the study in humans would be challenging.

The study’s applications

Nevertheless, Dr. Krauss was somewhat optimistic about the implications of this NIH research.

He hoped that the demonstration of the effects of PEDF loss “will now allow the use of this model to apply potential therapeutic measures to increase PEDF and/or the application of proposed therapeutic measures to counteract the damaging effects of PEDF depletion.”

Dr. Becerra said that she and fellow researchers will continue exploring “ways to use PEDF-derived peptides or mimics as a therapeutic for humans.”

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Adding Humor to Your Lingerie Collection: The Southern Sisters Can I Get A Woof Woof Dawg Nation Ladies Thong in Red & Black

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Looking for a way to add some humor and personality to your lingerie collection? Look no further than the Southern Sisters Can I Get A Woof Woof Dawg Nation Ladies Thong in red and black.

This funny thong for women is not only stylish, but it’s also a great way to show off your love for your furry friends. The design features a playful paw print pattern in bold red and black, with the phrase “Can I Get A Woof Woof” emblazoned across the waistband.

But why settle for boring, plain underwear when you can have something fun and unique like this thong? Wearing funny lingerie like this is a great way to add some personality to your intimate apparel and make getting dressed in the morning a little more fun.

So, whether you’re looking for a cute and quirky gift for a fellow dog lover, or just want to treat yourself to something a little more playful, this Southern Sisters thong is definitely worth checking out.

But this isn’t the only funny thong option out there for women. In fact, there are plenty of other humorous styles to choose from if you’re looking to add some levity to your lingerie drawer.

For example, there are thongs with cheeky phrases like “I put the ‘sin’ in single” or “I’m not arguing, I’m just explaining why I’m right.” These types of funny thongs are perfect for bachelorette parties or just for a good laugh with your girlfriends.

There are also plenty of thongs with cute and quirky designs, like ones with animal prints or fun patterns. These can be a great way to show off your playful side, even if you’re the only one who knows what’s underneath your clothes.

But why stop at just thongs? There are plenty of other types of funny lingerie for women who want to add some humor to their undergarments.

For example, there are bras with funny sayings or quirky designs, like ones with cupcakes or unicorns. There are also cute and quirky pajama sets with fun prints or phrases that are sure to make you smile.

Ultimately, the key to finding the right funny lingerie for you is to figure out what makes you laugh and what you feel comfortable wearing. After all, the point of lingerie is to make you feel confident and sexy, and adding a little humor to the mix can only enhance that.

So, whether you opt for the Southern Sisters Can I Get A Woof Woof Dawg Nation Ladies Thong or another type of funny lingerie, embrace your playful side and have some fun with your undergarments. Life’s too short to take everything too seriously, even your underwear!

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Embracing Comfort in the Beauty Industry GoBeauty Studios Provides Exclusive Rental Spaces for Professionals

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The quest for comfort has become a defining aspect of the 21st century, with enticing headlines showcasing everything from opulent buses to sumptuous sofas. As people become increasingly accustomed to convenience, they seek to incorporate comfort into all facets of their lives.

The beauty industry has not been left behind in this trend. The days of applying hair dye or nail polish while perched on a kitchen chair, accompanied by hours of lingering chemical smells, are long gone. Today’s beauty professionals opt for private spaces that uphold personal boundaries and provide a high-quality experience for their clients. The ideal workspace for beauty specialists should feature fresh renovations, attractive design, effective ventilation systems, natural lighting, practical furniture, and a washbasin.

GoBeauty Studios, a Ukrainian company, has stepped in to address the demand for comfortable and private workspaces. With ten locations already established in Kyiv and a presence in Zaporizhzhia, the company offers fully-equipped studios tailored to various beauty services, such as:

  • Cosmetology and massage
  • Hairdressing services
  • Manicure
  • Brow art and makeup

Each studio is equipped with a security system, 24/7 access for beauty professionals, Wi-Fi, and a coffee machine. The rental fee includes utilities, common area cleaning, and continuous support. This arrangement empowers specialists to create their own brand, expand their client base, and keep 100% of their earnings.

GoBeauty Studios (https://gobeautystudios.com/) further enhances the experience for beauty professionals and their clients by offering a free GoBeauty mobile app. This app allows professionals to manage schedules, oversee bookings, communicate with clients using a dedicated messenger, and process card payments. Clients can use the GoBeauty mobile app or visit the website (https://gobeauty.space) to discover available experts in their city and conveniently book services without the need for disruptive phone calls.

Despite the ongoing challenges in Ukraine, GoBeauty Studios remains committed to growth and plans to expand its network of studios both nationally and internationally.

The beauty hubs network is a new popular format of work in the beauty sphere in Ukraine and beyond. The company’s plans for the near future include expansion of the location’s network, not only within Ukraine but possibly abroad as well. Likely, GoBeauty Studios will soon appear in your city!

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Should You Buy A Lab-Grown Diamond? Here’S What You Need To Know

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The decision to buy a lab grown diamonds should be made with careful consideration. Lab-grown diamonds are created using advanced technology, allowing them to have the same physical and chemical properties as natural mined diamonds. They are also typically cheaper than traditional diamonds since they don’t require any mining or labor costs associated with extracting from the ground.

However, there can be differences in the quality of lab-grown diamonds compared to natural stones, which could affect their value over time. It is important to research what type of certification was used when grading a particular stone before making any purchase decisions. Additionally, you should consider how much importance you place on sourcing materials ethically and environmentally friendly methods for procurement when deciding if a lab-grown diamond is right for your needs.

Lab-grown diamonds are becoming increasingly popular among diamond buyers due to their ethical production process and lower cost. If you’re considering buying a lab-grown diamond, it’s important to do your research first. Not all lab-grown diamonds are created equal — make sure you understand the quality of the gemstone before committing to purchase one.

Additionally, check for certification from an independent laboratory such as GIA or AGS that can confirm authenticity and grade the stone accordingly. With this information in hand, you can then be confident about making your decision whether a lab-created diamond is right for you!

 

How are Lab-Grown Diamonds Different from Mined Diamonds

Lab-grown diamonds are created in a laboratory and mined diamonds come from the earth. Here’s how they differ:

  • Appearance: Lab-created diamonds have identical physical properties to natural stones and appear almost indistinguishable with the naked eye, while mined diamonds can vary slightly in color and clarity.
    • Cost: Generally, lab-made stones cost significantly less than those found naturally due to fewer production costs associated with their creation. • Sustainability & Ethics: Lab-grown diamonds are conflict free, meaning they do not involve any unethical practices such as child labor or environmental damage; whereas mined diamond sources often lack transparency when it comes to their sourcing methods. Overall, lab-grown diamonds offer an alternative choice for ethical jewelry without sacrificing quality or aesthetics.

Are Lab-Grown Diamonds of the Same Quality As Mined Diamonds

Lab-grown diamonds are of the same quality as mined diamonds. They have essentially identical chemical, physical, and optical properties. The main differences between these two types of diamonds include:

• Origin – Lab-grown diamonds are created in a laboratory using technological methods while mined diamonds occur naturally underground. • Cost – Lab-grown diamonds tend to be more cost effective since they don’t require extracting from the earth or sorting through tons of debris for them. • Environmental Impact – Mined Diamonds result in environmental damage due to mining processes whereas lab grown stones do not cause any harm to the environment.

Overall, lab-grown and mined diamonds are virtually indistinguishable when it comes to their value and beauty; they both offer stunning engagement rings that will last a lifetime!

 

How Much Does It Cost to Buy a Lab Grown Diamond Compared to One That Has Been Naturally Mined

A lab grown diamond, also known as a man-made or cultured diamond, costs approximately 30-40% less than one that has been mined from the earth’s crust. Benefits of Lab Grown Diamonds: • More affordable

• Environmentally friendly • Easier to acquire Lab grown diamonds are an excellent alternative for those who want the same look and feel of a traditional diamond without spending as much money.

They have become increasingly popular due to their affordability and environmental benefits compared to naturally mined diamonds.

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